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Why Are My Anti-Histamines Not Working?


Here’s why your anti-histamines like Benadryl, Allegra, Claritin, Rupatadine, Rupall etcetera are not helping to rid you of your persistent “allergy” symptoms.


These drugs are designed to suppress and alleviate pesky symptoms like itchy, watery eyes and hives and swelling, but what they do not do is actually target the root cause of your symptoms.


They are also designed to act on a surface level and to quickly leave the bodies blood stream; so If you pop a Benadryl and find that 4 hours later your symptoms start to inflame once again; that is the reason.


When your body is exposed to irritants histamine is released and your brain signals for certain histamine enzymes to start breaking it down and clearing it out. When you take an Anti-histamine drug it targets the symptoms only. Histamine clearing enzymes work to clear the irritant while the antihistamine helps to alleviate symptoms, but long term exposure to potential threats alerts your mast cells to over produce histamine.


When the drugs stop working to alleviate your symptoms it is a tell tale sign that your body is not clearing the histamine that is troubling you. This is largely because a build up has occurred in the body and as the drugs cease to do their job so do the enzymes trying to eradicate the problem from a cellular level.


Histamine build up in the body means that it’s in your blood stream, your tissue and your gut. In order for typical anti-histamines to help, you must work to help your enzymes to work at their full ability and you’re mast cells need to be signalled to stop over compensating. The healthiest way to do this is through minimizing your exposure to things that boost your histamine levels and by seeking out a biological treatment.


There are advanced biological drugs like Xolair available that will actually target your mast cells and signal to them to stop over producing histamine every time your body comes into contact with a foreign entity, but it can sometimes be tough to access it. I myself have waited years to be able to get this treatment and the first year alone cost $26,000.


A major way to help yourself is to minimize your histamine levels naturally. Its important to pay attention to high histamine foods that are in your daily diet. There are numerous anti-inflammatory supplements that work great in aiding to clear histamine as well. If you are in the midst of a massive outbreak and can’t find relief I recommend staying away from other “allergic” catalysts like dust, pollen, mold etc. A simple lifestyle change, even if just for a week or two will help your body recover more efficiently.


Bottom line: When your mast cells are over reacting to every little irritant and over producing histamine and anti-histamine drugs stop helping to alleviate your symptoms; you’re bodies enzymes need help clearing the histamine.


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For more info check out My blog posts titled; “Neuro-transmission & Food Histamine Intolerance” and “Maybe You Have A Histamine Intolerance”.

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